For decades, high-resolution protein structure determination relied heavily on techniques such as X-ray crystallography and NMR spectroscopy. While these methods remain powerful, crystallization requirements and sample-specific limitations can make some targets challenging to study. That limitation is now a relic of the past, thanks to Cryo-Electron Microscopy (Cryo-EM) . By rapidly...
One of the key challenges in modern structural biology is that widely used structure-determination and prediction approaches, including X-ray crystallography, cryo-EM, and AI-based structure prediction, often emphasize static or discrete structural states and may provide limited direct information on conformational dynamics in solution. Creative Biostructure, together with High Q Technologies,...
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